Electric Literature of 2695-48-9,Some common heterocyclic compound, 2695-48-9, name is 8-Bromo-1-octene, molecular formula is C8H15Br, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: In a glass vial with a screw cap containing methoxybenzoin (12 mg, 0.05 mmol) in acetonitrile (2 mL) and methanol (1.5 mL), alkene (0.50 mmol), BrCH2CN (120 mg, 1.00 mmol) and sodium ascorbate (198 mg, 1.00 mmol) were added consecutively. The vial was sealed with a screw cap and left stirring under household bulb irradiation (2 x 80 W household lamps, see photos below) for 16 hours. The desired product was isolated after purification by column chromatography.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 8-Bromo-1-octene, its application will become more common.
Reference:
Article; Voutyritsa, Errika; Nikitas, Nikolaos F.; Apostolopoulou, Mary K.; Gerogiannopoulou, Anna Dimitra D.; Kokotos, Christoforos G.; Synthesis; vol. 50; 17; (2018); p. 3395 – 3401;,
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