Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 10485-09-3, name is 2-Bromoindene, A new synthetic method of this compound is introduced below., Quality Control of 2-Bromoindene
The synthesis of the naphthyl ligand is shown in scheme 2. 2-bromoindene (6.66 g, 0.0342 moles) was taken in a round-bottomed flask and dissolved in toluene. Tetrakis triphenyl phosphine palladium (0.054gm, 8mol%) was added to the above solution and stirred for 10-15 min. To this solution the diboronic acid from step 1 (3g, 0.0156 moles) dissolved in ethanol (5ml) was added, followed by aqueous sodium carbonate (2M, 10ml). The reaction mixture was heated to 80C and stirred for 24hrs. It was cooled and extracted with dichloromethane (DCM; 5 x 50ml). The DCM portion was then extracted with water (2 x 50ml), dried over sodium sulfate and concentrated. The crude compound was purified by column chromatography by continuously eluting with hexane as the eluent. Crude yield = 3g; Purified yield = 1.6g (33%)
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; SAUDI BASIC INDUSTRIES CORPORATION; SABIC GLOBAL TECHNOLOGIES B.V.; SANKARAN, Nedumbamana; SHINGE, Prashant Sukumar; SHETTY, Sharankumar; CHANDRA, Girish; AL-SHAMMARI, Haif; AL-HUMYDI, Abdulaziz Hamad; NESAKUMAR, Edward Joseph; NADKARNI, Pradeep Jeeevaji; WO2015/28595; (2015); A1;,
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