Application of 28342-75-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 28342-75-8 name is 1,5-Dibromo-2,4-difluorobenzene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
At 160 , for there was added 1,5-dibromo-2,4-difluorobenzene (30.0g), phenol(31.2g), potassium carbonate (45.7 g) and NMP (150ml) was heated and stirred flask. Thereaction mixture was cooled until room temperature, the NMP was distilled off underreduced pressure after adding water and toluene were separated. After the solvent wasdistilled off under reduced pressure, silica gel short column (eluent: heptane / toluene= 1/2 (volume ratio)) was purified, thereby obtaining ((4,6-dibromo-1,3-phenylene ) bis(oxy)) diphenyl (44.0g).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1,5-Dibromo-2,4-difluorobenzene, and friends who are interested can also refer to it.
Reference:
Patent; Kwansei Gakuin School Corporation; Tian, Shanzuoci; Zhong, Zhongzongyiliang; Zhong, Daoguiyi; Ping, Jingdagui; Xiao, Yeyangping; Zhi, Lianyizhi; Ni, Jingping; Song, Xiawusi; Sheng, Tianlizhao; (405 pag.)CN105431439; (2016); A;,
Bromide – Wikipedia,
bromide – Wiktionary