Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2044-08-8, name is 1-Bromocyclohex-1-ene, A new synthetic method of this compound is introduced below., Formula: C6H9Br
To a solution of 1-bromocyclohexene6 (161 mg, 1.00 mmol) in Et2O (3 mL) at 78 C was addedtBuLi (6.0 mL, 1.46 M in pentane, 2.19 mmol). The resulting solution was stirred at 78 C for 0.5 h andRT for 20 min. After cooling to 78 C, MgBr2 solution (1.0 mL, 1.0 M in Et2O/benzene = 3:1, 1.00mmol) was added dropwise. The reaction mixture was stirred at 78 C for 10 min and a solution ofaldehyde 4a (150 mg, 0.48 mmol) in Et2O (4 mL) was added dropwise over 5 min. After stirring at78 C for 2 h, the reaction was quenched with sat. aq. NH4Cl (20 mL), and extracted with AcOEt (3 x20 mL). The organic layers were combined, washed with brine (20 mL), dried over MgSO4, andconcentrated in vacuo. The residue was purified by flash chromatography (silica gel, hexane/AcOEt =10:1) to afford 20g (161 mg, 85% yield) as a colorless oil.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Miyamoto, Hiroshi; Hirano, Tomohiro; Okawa, Yoichiro; Nakazaki, Atsuo; Kobayashi, Susumu; Tetrahedron; vol. 69; 45; (2013); p. 9481 – 9493;,
Bromide – Wikipedia,
bromide – Wiktionary