Related Products of 460-00-4, A common heterocyclic compound, 460-00-4, name is 1-Bromo-4-fluorobenzene, molecular formula is C6H4BrF, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: An oven-dried Schlenk tube was charged with CuI (4 mg, 0.02 mmol), aryl bromide (1 mmol), L10 (9 mg, 0.04 mmol) and CsOH (504 mg, 3 mmol) (or KOH (168 mg, 3 mmol)). The tube was evacuated and backfilled with argon, and then DMSO (1 mL), t-BuOH (1 mL) and H2O (0.1 mL) were added. The reaction mixture was stirred at indicated temperatures until the starting material was completely converted (monitored by TLC). The cooled solution mixture was acidified to pH = 1-2 with 2 N HCl, and then extracted with EtOAc. The combined organic layers were washed with H2O and brine, dried over Na2SO4. After removal of the solvent in vacuo, the residue was purified with flash chromatography to give the corresponding phenol.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Jia, Jianhuan; Jiang, Chenglin; Zhang, Xiaojing; Jiang, Yongwen; Ma, Dawei; Tetrahedron Letters; vol. 52; 43; (2011); p. 5593 – 5595;,
Bromide – Wikipedia,
bromide – Wiktionary