At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Bromo-4-isopropylbenzene, and friends who are interested can also refer to it.
Reference of 586-61-8, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 586-61-8 name is 1-Bromo-4-isopropylbenzene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Example 1This example illustrates the preparation of Compound E1 , 3-iso- propyl-N6,N6,N12,N12-tetrakis(3,4-dimethylphenyl)-chrysene-6,12-diamine a. Preparation of (Z)-1 -(4-/so-propylstyryl)naphthalene.In a drybox, 1-vinylnaphthalene (9.80 g, 63.5 mmol) and 4- bromocumene (11.5 g, 57.8 mmol) were placed into a 250 ml RB flask and dissolved in 80 ml of dry DMF. Palladium catalyst (frans-di(mu- acetato)bis[o-(di-o-tolylphosphino)benzyl] dipalladium (II), 0.542 g, 0.58 mmol) and sodium acetate (7.11 g, 86.6 mmol) were added last, followed by 20 ml of dry DMF. The flask was capped, taken out of the box and attached to a condenser flushed with nitrogen. The reaction mixture was stirred at 120 0C for 60 hours. Solution was cooled to room temperature and poured into 750 ml of water. Aqueous layer was extracted with CH2Cb (3×500 ml). Combined organic layers were rinsed with water and brine (500 ml each), dried over MgSO4 and volatiles were removed under vacuum. Crude product was adsorbed onto 25 g of silica, loaded onto a 4″ column and eluted with hexane first, then with 20% CH2CI2 in hexane. The first fraction was concentrated and residue was dried under high vacuum to 6.3 g (40 %) of the desired product. 1H NMR is analogous to the one reported in the literature (Beckmann et al., Solid St. Nuc. Mag. Res., 1998, 12, 251 ).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Bromo-4-isopropylbenzene, and friends who are interested can also refer to it.
Reference:
Patent; E. I. DU PONT DE NEMOURS AND COMPANY; WO2008/147721; (2008); A1;,
Bromide – Wikipedia,
bromide – Wiktionary