Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4101-68-2, name is 1,10-Dibromodecan, A new synthetic method of this compound is introduced below., Computed Properties of C10H20Br2
General procedure: For example, to a solution of 7-hydroxycoumarin (5.0 g, 31.0 mmol) in acetone (60.0 mL) was added anhydrous K2CO3 (6.9 g, 50.0 mmol) and triethylamine (1.0 mL) at room temperature. After stirring at room temperature for 30 min, 1, 2-dibromoethane (12.6 g, 62.0 mmol) was added to the reaction mixture, and the whole was refluxed at 60C for 24 h. Then the reaction mixture was filtered, and the filtrate was evaporated under reduced pressure. The residue was treated with water (200.0 mL) and extracted with dichloromethane (4×200.0 mL). The organic layer was combined, dried with anhydrous Na2SO4, and concentrated under reduced pressure. The crude product was purified via silica gel column chromatography with mixed petroleum ether and ethyl acetate (5:1, v/v) as eluent, and resulted in a white solid.
The synthetic route of 4101-68-2 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Hu, Yang; Chen, Weichao; Shen, Yufeng; Zhu, Bin; Wang, Gao-Xue; Bioorganic and Medicinal Chemistry Letters; vol. 29; 14; (2019); p. 1749 – 1755;,
Bromide – Wikipedia,
bromide – Wiktionary