Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4117-09-3, name is 7-Bromo-1-heptene, A new synthetic method of this compound is introduced below., Formula: C7H13Br
Magnesium chips (0.24 g, 10.1 mmol) were protected with argon.And add 5mL of dry THF to take 7-bromo-1-heptene(1.5 mL, 9.6 mmol) in a disposable syringe,First, a small amount of 7-bromo-1-heptene (about 10% by volume)Infused into the reaction solution,Then add a small amount of 1,2-dibromoethane (about 0.1mL) to initiate the reaction, and then slowly add the remaining 7-bromo-1-heptene (added in 5min)Into the reaction solution, after the addition is complete,Heated back to reflux for 30 min (about 60 C),A freshly prepared Grignard reagent of 7-bromo-1-heptene was obtained.The nitrone formula (3-1) (2 g, 4.8 mmol) was dissolved in 20 mL of dry THF, argon-protected and cooled to 0 C.The above-mentioned new Grignard reagent (5mL)Add dropwise to the reaction solution (added in 2 minutes)The reaction was stirred for 1 h. The reaction was quenched with saturated aq.Dry over anhydrous MgSO 4, filtered and evaporated.2.5 g of the crude product of the product hydroxyamine (4-1) was obtained.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Chinese Academy Of Sciences Chemical Institute; Yu Chuyi; Song Yingying; Jia Yuemei; Li Yixian; Jia Tengdun; (29 pag.)CN105085356; (2018); B;,
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