Synthetic Route of 18599-22-9, A common heterocyclic compound, 18599-22-9, name is 4-Bromo-3,3,4,4-tetrafluorobut-1-ene, molecular formula is C4H3BrF4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
4-Bromo-3,3,4,4-tetrafluoro-1-butene (8.7 g, 42 mmol), anthracene (5.0 g, 28 mmol), and toluene (100 g) were put into a 300 mL pressure resistant reaction container and reacted at 150 C. for 24 hours. Subsequently, after cooling to room temperature, the resultant was concentrated using a rotary evaporator. Methanol (50 g) was added to the concentrate, followed by stirring. The precipitated solid was subjected to filtration. Then, the filtrate was dried under a reduced pressure to obtain an intermediate 4b (6.0 g, yield=55.6%).
The synthetic route of 18599-22-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; TOKYO OHKA KOGYO CO., LTD.; IKEDA, Takuya; SHIOSAKI, Masahiro; ARAI, Masatoshi; KOMURO, Yoshitaka; (170 pag.)US2019/361345; (2019); A1;,
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