Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 10016-52-1, name is 2,8-Dibromodibenzo[b,d]furan, A new synthetic method of this compound is introduced below., HPLC of Formula: C12H6Br2O
A mixture of 10 g (30.7 mmol) of 2,8-dibromodibenzo[b,d]furan, 6.07 g (30.7 mmol) of [1,1?-biphenyl]-2-ylboronic acid, 0.35 g (0.3 mmol) of Pd(Ph3)4, 30.7 ml of 2M Na2CO3, 80 ml of EtOH and 160 ml of toluene was degassed and placed under nitrogen, and then heated to reflux for 12 hrs. After the reaction finished, the mixture was allowed to cool to room temperature. Subsequently, the solvent was removed under reduced pressure, and the crude product was purified by column chromatography, yielding 6.8 g of 2-([1,1?-biphenyl]-2-yl)-8-bromodibenzo[b,d]furan as white solid (55.5%). 1H NMR (CDCl3, 400 MHz): chemical shift (ppm) 8.19(s, 1H), 7.88-7.81 (m, 5H), 7.74-7.72 (s, 2H), 7.52-7.39 (m, 7H)
The synthetic route of 10016-52-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; LUMINESCENCE TECHNOLOGY CORPORATION; Yen, Feng-Wen; Chuang, Li-Chieh; (84 pag.)US2020/111971; (2020); A1;,
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