Application of 59907-13-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 59907-13-0 as follows.
Intermediate 5; 2-Fluoro-6-methylDhenylboronic acid; A 500 mL 3-neck round bottom flask, equipped with a magnetic stirring bar, thermometer, and nitrogen gas inlet, was charged with 2-bromo-1-fluoro-3-methylbenzene (6.95 g, 36.80 mmol), B(O1Pr)3 (10.38 g, 12.7 mmol), and 60 mL of anhydrous ether under nitrogen. The mixture was cooled to -70 0C with a dry ice/acetone bath, then a solution of 1BuLi (1.7 M in pentane, 47.6 mL, 80.96 mmol) was added dropwise keeping internal temperature below -50 0C. The mixture was warmed to -5 0C and stirred for 30 min., then 35 mL of 5M HCI was added and stirred at room temperature for an additional 30 min. The mixture was extracted with MTBE (3×70 mL), the extract was washed with brine (2×50 mL), and evaporated under reduced pressure keeping the temperature below 20 0C. The resulting residue was dissolved in a mixture of 100 mL of aqueous 2M NaOH and 50 mL of ether. The mixture was washed with ether (3×50 mL), and the aqueous layer was carefully acidified with cone. HCI to pH 1 in an ice bath. The resulting precipitate was collected by vacuum filtration, washed with cold water (2×10 mL), and dried under vacuum at room temperature to give 2- fluoro-6-methylphenylboronic acid (1.63 g) as a tan solid. M. P 110-112 0C; 1H NMR (300 MHz, DMSO-d6): delta 8.40 (2H), 7.21 (1H), 6.96 (1H), 6.87 (1H), 2.30 (3H).
According to the analysis of related databases, 59907-13-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; PFIZER INC.; WO2006/51410; (2006); A1;,
Bromide – Wikipedia,
bromide – Wiktionary