Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 67567-26-4, name is 4-Bromo-2,6-difluoroaniline, A new synthetic method of this compound is introduced below., Computed Properties of C6H4BrF2N
A mixture suspension of 4-bromo-2,6-difluoroaniline (7, 25.85 g) and copper(I) cyanide (16.70 g) in NMP (60 mL) was stirred at reflux temperature for 1.5 h and then cooled down to room temperature. To the mixture was added 1,2-diaminoethane (23 mL) and the mixture was poured into water (150 mL). The mixture was extracted with ethyl acetate and the organic layer was washed with 10 wt % 1,2-diaminoethane solution in water and water, and then dried. The desiccant was removed by filtration and the filtrate was evaporated in vacuo. The resulting residue was purified by silica gel column chromatography (hexane-ethyl acetate) to obtain 8 (16.54 g, 86%) as a pale yellow solid: 1H NMR (DMSO-d6) delta 6.36 (2H, s), 7.50 (2H, dd, J = 2.7, 6.7 Hz); EI-MS m/z 154 [(M)+].
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Negoro, Kenji; Yonetoku, Yasuhiro; Misawa-Mukai, Hana; Hamaguchi, Wataru; Maruyama, Tatsuya; Yoshida, Shigeru; Takeuchi, Makoto; Ohta, Mitsuaki; Bioorganic and Medicinal Chemistry; vol. 20; 17; (2012); p. 5235 – 5246;,
Bromide – Wikipedia,
bromide – Wiktionary