Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 327-52-6, name is 1-Bromo-2,4,5-trifluorobenzene, A new synthetic method of this compound is introduced below., Application In Synthesis of 1-Bromo-2,4,5-trifluorobenzene
A 1-L, one-necked, round-bottom flask, equipped with a Tefloncoatedmagnetic stirring bar, was removed from a drying oven at150 C, sealed while hot with a rubber septum, purged with dry N2,and cooled to r.t. (22 C). 1-Bromo-2,4,5-trifluorobenzene (1; 50.0mL, 90.0 g, 0.427 mol; Oakwood Products) and anhydrous THF(400 mL) were added from a syringe, and the flask was submergedin a bath of acetone cooled to -78 C with dry ice. A 2.0 M solutionof DIPEA in THF (224 mL, 0.448 mol; Sigma-Aldrich) was addedwith stirring over 5 min, and the resulting mixture was stirred for anadditional 10 min. The dry ice-acetone bath was removed and replacedwith an ice-water bath. The mixture was stirred for an additional30 min then the ice-water bath was removed and the flaskwas resubmerged in the dry ice-acetone bath. The mixture wasstirred for 10 min at -78 C, then aldehyde 2 (50.4 mL, 71.7 g, 0.448mol; Oakwood Products) was added from a syringe. The resultingmixture was stirred for an additional 10 min before the dry ice-acetone bath was removed. The flask was then warmed to r.t., andthe mixture was stirred at r.t. for 3 h. The reaction was thenquenched by addition of sat. aq NH4Cl (50 mL), and the resultingbiphasic mixture was diluted with H2O (300 mL) and Et2O (200mL). The two phases were separated, and the aqueous fraction wasextracted with Et2O (2 × 300 mL). The organic fractions were combined,dried (Na2SO4), and concentrated by rotary evaporation togive alcohol 3 as a viscous oil.
The synthetic route of 327-52-6 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Woydziak, Zachary R.; Fu, Liqiang; Peterson, Blake R.; Synthesis; vol. 46; 2; (2014); p. 158 – 164;,
Bromide – Wikipedia,
bromide – Wiktionary