Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 176317-02-5, name is 1-Bromo-2,3,4-trifluorobenzene, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 176317-02-5
EXAMPLE 4 This Example illustrates the preparation of 1,1-bis(4-trifluoromethoxyphenyl)-2-(2H-tetrazol-2-yl)propanol (compound no. IX, Table I). A proportion (ca. 25 cm3) of a solution of 4-bromotrifluoromethoxybenzene (45.79 g) in dry tetrahydrofuran (200 cm3) was added to a gently stirred mixture of magnesium turnings (4.56 g) and dry tetrahydrofuran and a crystal of iodine under a nitrogen atmosphere. When the exothermic reaction had commenced the temperature of the mixture was maintained at the reflux temperature by the careful addition of the remaining 4-bromotrifluorobenzene followed by heating the mixture for a further hour at the reflux temperature. The mixture was cooled to the ambient temperature and stirred under a nitrogen atmosphere whilst a solution of methyl 2-(2H-tetrazol-2-yl)propionate (13.95 g) in dry tetrahydrofuran (60 cm3) was added dropwise, followed by heating the mixture at the reflux temperature for 30 minutes. The mixture was cooled and poured into water (500 cm3) and the resultant mixture acidified with 2N hydrochloric acid (250 cm3) and extracted with diethylether (3*400 cm3). The extracts were combined, dried over anhydrous magnesium sulphate and concentrated by evaporation of the solvents under reduced pressure to give a residual oil (30.5 g). This was subjected to purification by chromatography on a silica gel column using a mixture of n-hexane (4 parts by volume) and ethyl acetate (1 part by volume), and thereafter by h.p.l.c. of the fractions containing the product using the same eluant, to yield 1,1-bis(4-trifluoromethoxyphenyl)-2-(2H-tetrazol-2-yl)propanol (10.0 g), which crystallized on standing to a white solid, m.p. 68-70 C. Nmr (CDCl3) delta: 1.55 (d, 3H); 4.8 (s, 1H); 6.1 (q, 1H); 7.4 (m, 8H); 8.4 (s, 1H).
According to the analysis of related databases, 176317-02-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Imperial Chemical Industries PLC; US4831047; (1989); A;,
Bromide – Wikipedia,
bromide – Wiktionary