In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-4-fluoro-2-methylbenzene, other downstream synthetic routes, hurry up and to see.
Electric Literature of 452-63-1, The chemical industry reduces the impact on the environment during synthesis 452-63-1, name is 1-Bromo-4-fluoro-2-methylbenzene, I believe this compound will play a more active role in future production and life.
4-Fluoro-2-methylphenylacetic acid To a 2L flask containing 2-dicyclohexylphosphino-2′-(N, N- dimethylamino)biphenyl.(3.76g) and Pd(OAc)2 (1.02g) were added 396 mL of IN LHMDS in hexanes, then 400 mL of toluene under N2. The solution was cooled to -10 0C and tButyl acetate (49 mL was added. The solution was stirred at -10 0C for 10 min and was added 2-bromo-5-fiuoro toluene. The mixture was heated at 80 0C for 15 min and was washed with NH4Cl and NaCl, dried with Na2SO4, filtered and concentrated. The crude was purified by flash chromatorghy with EtOAc/hexanes = 1 :30 to give tert-bvAyl (4-fluoro-2-methylphenyl)acetate (21.85g).The pure ester was dissolved in 60 ml Of CH2Cl2 was added 6 drops of anisole and 60 ml OfCFaCO2H and the solution was atirred at rt for 16hr. Upon removal of volatiles, the residue was dried three times by dissolving in toluene to afford 20.02 g of the title compound. 1H- NMR (CDCI3): delta 2.35 (s, 3H), 3.67 (s, 2H), 6.92-6.95 (m, 2H), 7.19 (d of d, IH, J = 8.2, 5.7 Hz) ppm.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-4-fluoro-2-methylbenzene, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; MERCK & CO., INC.; WO2007/75528; (2007); A2;,
Bromide – Wikipedia,
bromide – Wiktionary