These common heterocyclic compound, 76153-06-5, name is 5-Bromo-3-methylbenzene-1,2-diamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 5-Bromo-3-methylbenzene-1,2-diamine
A mixture of 5-bromo-3-methylbenzene-l , 2-diamine (2.5 mmol, 0.5 g) , was suspended in trimethylorthoformate (1042) (34 mL) and para-toluene sulfonic acid monohydrate (0.17 g) was added. The suspension was heated at 115 C for 1.5 hours, and then cooled to room temperature. The mixture was diluted with dichloromethane and washed with (1043) saturated sodium bicarbonate solution and brine. The organic extracts were combined, passed through a phase separator cartridge and concentrated under reduced pressure to afford the crude title compound as a brown solid (0.78 g, >100%) which was used without further purification.
The synthetic route of 5-Bromo-3-methylbenzene-1,2-diamine has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ONO PHARMACEUTICAL CO., LTD.; SAITO, Tetsuji; HIGASHINO, Masato; KAWAHARADA, Soichi; LEWIS, Arwel; CHAMBERS, Mark Stuart; RAE, Alastair; HIRST, Kim Louise; HARTLEY, Charles David; WO2015/115673; (2015); A1;,
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