Reference of 2862-39-7, These common heterocyclic compound, 2862-39-7, name is 2-Bromo-N,N-dimethylethanamine hydrobromide, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Methyl4-[(2-cyclopentyl-6-methyl-5-oxo-2,6,9,11-tetrazabicyclo[5.4.0]undeca-8,10,12-trien-10-yl)amino]-3-hydroxy-benzoate (Intermediate 73; 63 mg, 0.15 mmol) was dissolved in DMA (2 mL) and treated sequentially with potassium carbonate powder (fine mesh; 106 mg, 0.79 mmol) and dimethylaminoethyl bromide hydrobromide (ASDI; 61 mg, 0.26 mmol). The reaction mixture was heated to 100 C., with stirring for 1 hour and allowed to cool overnight, before pouring into water (40 ml). The mixture was extracted with DCM (2×30 ml) and the organic extracts washed with brine, dried over magnesium sulphate, filtered and evaporated to give a brown liquid which was taken up in methanol and poured onto an SCX-3 cartridge (2 g). The cartridge was washed with methanol (30 ml) before eluting products with 2M ammonia/methanol (20 ml). The ammoniacal wash was evaporated to give the title compound as a brown gum (41 mg, 57%)MS m/z 483.4 [M+H]+, Retention Time 2.41 minutes.
The synthetic route of 2862-39-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ASTRAZENECA AB; US2008/9482; (2008); A1;,
Bromide – Wikipedia,
bromide – Wiktionary