Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 937046-98-5, name is 7-Bromopyrrolo[2,1-f][1,2,4]triazin-4-amine, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 7-Bromopyrrolo[2,1-f][1,2,4]triazin-4-amine
To a stirred suspension of Intermediate B (2.50 g, 9.39 mmol) in THF (50 ml_) was added chlorotrimethylsilane (2.98 mL, 23.47 mmol), dropwise. The mixture was stirred at rt for 3 h and 2-propylmagnesium chloride (2M in THF; 24.64 mL, 49.29 mmol) was added dropwise. The suspension immediately went into solution. The mixture was stirred at rt for 3 h and 1-Boc-3-piperidone (3.51 g, 17.60 mmol) was added in one portion. The reaction was stirred at rt for 16 h. The reaction was poured over a mixture of ice and saturated, aqueous ammonium chloride (250 mL). The mixture was allowed to warm to rt and was extracted with EtOAc (3 x 100 mL). The combined organic layers were washed with brine, dried (Na2SO4), and concentrated to dryness. The crude residue was purified by ISCO chromatography using a gradient of 50 to 75% ethyl acetate in hexanes to afford 2.77 g (71%) of the desired product. ES-MS m/z 334.08 [M+H]+, HPLC RT (min) 0.97.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 937046-98-5.
Reference:
Patent; BAYER PHARMACEUTICALS CORPORATION; WO2007/56170; (2007); A2;,
Bromide – Wikipedia,
bromide – Wiktionary