Synthetic Route of 156682-52-9,Some common heterocyclic compound, 156682-52-9, name is 1,4-Dibromo-2,3-difluorobenzene, molecular formula is C6H2Br2F2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
-PrMgCl-LiCl (2 M, 2.03 mL) at -40C was added to a solution of Compound BD4-3 (0292) (1.00 g, 3.68 mmol) in THF (20.00 mL) at -40C. The mixture was stirred at -40C for 1 hour and again stirred at -7C for another 1 hour. The mixture was then cooled to -30C. DMF (349.66 mg, 4.78 mmol) at -23C was added in one portion. The mixture was stirred while keeping a temperature range of -25C to 15C for 3.5 hour. TLC indicated when the reaction was completed. The reaction mixture was poured into H2SO4 (100 mL, 1M) cooled to 0C by ice bath, and then the resulting mixture was extracted with EtOAc (20 mL * 3). The combined organic layers of the reaction mixture were washed with brine (30 mL * 3), dried over Na2SC>4, filtered and concentrated under reduced pressure to afford Compound BD4-4 (800.00 mg, crude) as a yellow solid.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,4-Dibromo-2,3-difluorobenzene, its application will become more common.
Reference:
Patent; THE BROAD INSTITUTE, INC.; VACCA, Joseph, P.; (103 pag.)WO2018/75871; (2018); A1;,
Bromide – Wikipedia,
bromide – Wiktionary