Related Products of 1347736-74-6,Some common heterocyclic compound, 1347736-74-6, name is 4,7-Dibromo-5-fluoro-2,1,3-benzothiadiazole, molecular formula is C6HBr2FN2S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A dried flask was charged with 4,7-Dibromo-5-fluoro-2,1,3-benzothiadiazole (3.0 g, 9.6 mmol), compound 5(3.83 g, 9.58 mmol), Pd2dba3 (0.174 g, 0.19 mml), PPh3 (0.202 g,0.77 mmol) and 100ml of toluene. The reaction mixturewas heatedto 80 C for 48 h. Upon cooling, 30 mL of 2 M HCl was added andthen stirred for 1 h. After extract with dichloromethane, the solventwas removed by vacuum evaporation, and then recrystallized withchloroform/methanol and filtered. The solid was washed withcopious methanol, and dried under vacuum for 24 h. Compound 6was a red solid.Yield: 40.9% (1.67 g). 1H NMR (CDCl3, 500 MHz, [ppm]): delta 9.904(s, 1H), 8.066 (d, 1H, J 4 Hz), 7.764 (m, 2H), 7.458 (d, 1H, J 4 Hz),7.392 (d, 1H, J 4 Hz); APCI: m/z 425.0, calcd 423.88.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4,7-Dibromo-5-fluoro-2,1,3-benzothiadiazole, its application will become more common.
Reference:
Article; Lim, Bogyu; Sun, Huabin; Noh, Yong-Young; Dyes and Pigments; vol. 146; (2017); p. 520 – 528;,
Bromide – Wikipedia,
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