Related Products of 1435-53-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1435-53-6 name is 2,4-Dibromo-1-fluorobenzene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
General procedure: 8.7 1,3-Di(2-thienyl)-4-fluorobenzene (11g): Starting with 10 (100 mg, 0.39 mmol), Cs2CO3 (190 mg, 0.50 mmol), Pd(PPh3)4 (3 mol%), 2-thienylboronic acid (49 mg, 0.39 mmol) and 1,4-dioxane (4 mL), 11g was isolated as a colorless solid (49 mg, 48%). Mp 91-93 C. 1H NMR (300 MHz, CDCl3): delta = 7.00-7.06 (m, 2H, ArH), 7.22-7.34 (m, 5H, ArH), 7.41-7.43 (m, 1H, ArH), 7.52-7.57 (m, 1H, ArH). 13C NMR (75.46 MHz, CDCl3): delta = 113.4 (d, J = 24.5 Hz, CH), 121.1 (d, J = 13.5 Hz, C), 121.8 (d, J = 3.1 Hz, CH), 123.8 (CH), 125.6 (CH), 125.8 (d, J = 4.5 Hz, CH), 126.3 (d, J = 7.1 Hz, CH), 127.8 (CH), 128.3 (CH), 129.0 (d, J = 4.2 Hz, CH), 134.9 (d, J = 9.4 Hz, C), 136.9 (d, J = 3.87 Hz, C), 142.6 (d, J = 2.9 Hz, C), 159.2 (d, JCF = 250.2 Hz, CF). 19F NMR (282.4 MHz, CDCl3): delta = -107.4 (CF). IR (ATR, cm-1): , 3067 (w), 2956 (w), 2871 (w), 1886 (w), 1799 (w), 1724 (w), 1605 (w), 1555 (w), 1484 (w), 1421 (w), 1355 (w), 1289 (w), 1244 (w), 1177 (w), 1121 (w), 1071 (w), 999 (w), 960 (w), 866 (w), 841 (w), 808 (m), 746 (w), 696 (m), 613 (w), 561 (w), 529 (w). GC-MS (EI, 70 eV); m/z (%) = 260 (100) [M]+, 215 (13). HRMS (EI) calcd. for C14H9FS2 [M]+: 260.01242; found 260.01360.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2,4-Dibromo-1-fluorobenzene, and friends who are interested can also refer to it.
Reference:
Article; Sharif, Muhammad; Maalik, Aneela; Reimann, Sebastian; Feist, Holger; Iqbal, Jamshed; Patonay, Tamas; Villinger, Alexander; Langer, Peter; Journal of Fluorine Chemistry; vol. 146; (2013); p. 19 – 36;,
Bromide – Wikipedia,
bromide – Wiktionary