Reference of 2270-59-9,Some common heterocyclic compound, 2270-59-9, name is 5-Bromo-2-methylpent-2-ene, molecular formula is C6H11Br, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A mixture of 5-bromo-2-methylpent-2-ene (0.66 mL, 5.0 mmol) in CH3CN (15 mL) was added 2-hydroxyisoindoline-l,3-dione (3.33 g, 6.0 mmol) and DBU (4.5 mL, 30 mmol) was heated at 1000C for 4 h. Work-up analogous to the procedure described in Example 58 afforded2-(4-methylpent-3-enyloxy)isoindoline-l,3-dione (1.14g, 90%) as a viscous oil.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Bromo-2-methylpent-2-ene, its application will become more common.
Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; WO2009/97578; (2009); A1;,
Bromide – Wikipedia,
bromide – Wiktionary