Synthetic Route of 201138-91-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 201138-91-2, name is 4,6-Dibromodibenzo[b,d]furan belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
i. Weigh 32.6 mg of 4,6-dibromobenzofuran and 121 mg of the compound of formula (8) and add it to a mixed solvent containing toluene and ethanol (the volume ratio is toluene: ethanol = 12: 1),Protected by nitrogen, heated to 80 C, and reacted for 20 minutes.Then add 2mg of tris (dibenzylideneacetone) dipalladium,13 mg of bis (2-diphenylphosphine) phenyl ether and 1 ml of potassium carbonate aqueous solution (2 mol / L), heated to 95 C, and reacted for 10 hours.Stop the reaction, extract, collect the organic phase, evaporate the organic solvent under reduced pressure to obtain the crude product, and purify by column chromatography to obtain the compound of formula (VII).The eluent was a mixed solvent of chloroform and n-hexane (the volume ratio was chloroform: n-hexane = 1: 2).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4,6-Dibromodibenzo[b,d]furan, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; China Petroleum University (East China); Liu Heyuan; Yan Xinyu; Li Xiyou; (8 pag.)CN110256384; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary