Adding a certain compound to certain chemical reactions, such as: 327-51-5, name is 1,4-Dibromo-2,5-difluorobenzene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 327-51-5, Quality Control of 1,4-Dibromo-2,5-difluorobenzene
Freshly titrated n-butyl lithium (27. 0 ml, 1. 39 M in hexanes) is added slowly (over about 30 minutes) to a-78 C solution of diethyl ether (90 ml) containing 1, 4-dibromo- 2, 5-DIFLUOROBENZENE (1, 10. 22 g, 0. 038 mol). The resulting yellow solution is stirred at-78 C for 2 hours to give a yellow suspension. Several pellets (-10) of dry ice are added to the suspension, which is then allowed to warm slowly to room temperature as it degasses (approximately 40 minutes). The resulting suspension is acidified with a 1 M aqueous solution of hydrochloric acid (500 ml), and the product extracted with diethyl ether (5 x 200 ml). The combined organics are washed with water (4 x 100 ml) and filtered. The ether solution is concentrated to approximately 200 ml under reduced pressure, and the product extracted into a saturated aqueous solution of sodium bicarbonate (3 x 200 ml). The combined aqueous extracts are washed with methylene chloride (3 x 100 ml) and acidified with hydrochloric acid. The product is extracted with diethyl ether (3 x 200 ml), and the combined organic extracts washed with water (2 x 200 ml), dried over magnesium sulfate, and concentrated under reduced pressure to give (2) as a pale yellow SOLID. 1H NMR (300 MHz, DMSO-d6) : 5 7. 74 (dd, JH-F = 8. 5 Hz, 6. 5 Hz, 1H), 7. 84 (DD, JH-F = 10. 0 Hz, 5. 5 Hz, 1H), 13. 7 (br, 1H, CO2H). 19F{1H} NMR (282 MHz, DMSO-d6) : No.-114. 0 (d, JF-F = 17. 0 Hz, 1F),-113. 6 (D, JF-F = 17. 0 Hz, 1F). I3C {LH} NMR (75 MHz, DMSO-D6) : No.113. 6 (dd, JC-F = 23. 5 Hz, 10. 0 Hz), 118. 4 (DD, JC-F = 26. 5 Hz, 2. 5 Hz, CH), 120. 0 (DD, JC-F = 19. 0 Hz, 12. 0 Hz), 122. 2 (D, JC-F = 28. 0 Hz, CH), 154. 4 (dd, JC-F = 245. 0 Hz, 5. 5 Hz, CF), 156. 8 (dd, JC-F = 251. 5 Hz, 4. 0 Hz, CF), 163. 4 (m, COXH).
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1,4-Dibromo-2,5-difluorobenzene, and friends who are interested can also refer to it.
Reference:
Patent; ACHILLION PHARMACEUTICALS, INC.; WO2005/19228; (2005); A1;,
Bromide – Wikipedia,
bromide – Wiktionary