Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 586-61-8, name is 1-Bromo-4-isopropylbenzene, A new synthetic method of this compound is introduced below., HPLC of Formula: C9H11Br
[00312j A mixture of 4-(benzyloxy)aniline (7.8 g, 39.03 mmol), 1-bromo-4- isopropylbenzene (8.5 g, 42.93 mmol), X-Phos (2.3 g, 4.68 mmol), Pd(OAc)2 (0.53 g, 2.34 mmol) and Cs2CO3 (50.9 g, 156.12 mmol) in toluene(150 mL) was purged with N2 and then reflux overnight. The reaction mixture was cooled to RT and filtered. The filtrate was concentrated and purified by silica column chromatography (PE:EA, 20:1) to give 7.1 g (57%) of the title compound. ?H NMR (CDC13, 300 MHz): oe 1.23 (d, J= 6.9 Hz, 6H), 2.77-2.92 (m, 1H), 5.04 (s, 2H), 6.87-6.94 (m, 4H), 7.01-7.04 (m, 2H), 7.08-7.10 (m, 2H), 7.3 1-7.46 (m, 5H). [M+H] Calc?d for C22H23N0, 318; Found, 318.
The synthetic route of 586-61-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; QUANTICEL PHARMACEUTICALS, INC.; BOLOOR, Amogh; KANOUNI, Toufike; STAFFORD, Jeffrey Alan; VEAL, James Marvin; WALLACE, Michael Brennan; (173 pag.)WO2016/44429; (2016); A1;,
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