Electric Literature of 3814-30-0,Some common heterocyclic compound, 3814-30-0, name is (Bromomethyl)cyclopentane, molecular formula is C6H11Br, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
N-(4-(ethylsulfonyl)benzyl)-4-(propylamino)benzamide (70 mg, 0.28 mmol) was added sequentially to a 50 mL vial.Bromomethylcyclopentane(45 mg, 0.28 mmol), anhydrous potassium carbonate (115 mg, 0.83 mmol),10 mL of acetonitrile, heated to reflux for 4 hours.The reaction was completed by TLC. Spin the solvent,Wash with saturated brine and dry over anhydrous sodium sulfate.Purification of petroleum ether by column chromatography: ethyl acetate 1:2,Obtained 30mg of white solid,The yield was 23.5%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route (Bromomethyl)cyclopentane, its application will become more common.
Reference:
Patent; Fudan University; Wang Yonghui; Qiu Ruomeng; Gong Juwen; Tian Jinlong; Huang Yafei; (65 pag.)CN109206346; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary