Synthetic Route of 58971-11-2,Some common heterocyclic compound, 58971-11-2, name is 3-Bromophenethylamine, molecular formula is C8H10BrN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
N-3-brornophenethyB-2,2,2-trifhioroacetamk1e. A vial was charged with 2(3bromophenyflethanamine (600 nig, 3 mnrol). methylene chloride (2.0 mL), and tri.tluoroacetie anhydride:0 4 niL 3 mmd) lrwthvlamine (0 X4 mL 6 mmd) xas carttull iddtd dtopxs ist I Ia rcxtmn n?is stirred for 1 h then concentrated. The residue was purified on silica gel (20% EtOAc/hexanes) to provide the hUe compound (773 mg, 87% yield). LCMS: Ri? 1.007 miii; M+H 296.2..
The synthetic route of 58971-11-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; VANDERBILT UNIVERSITY; CONN, Jeffrey, P.; HOPKINS, Corey, R.; LINDSLEY, Craig, W.; NISWENDER, Colleen, M.; EMMITTE, Kyle; BRONSON, Joanne; WU, Yong-Jin; PANARESE, Joe; ENGERS, Darren, W.; ENGERS, Julie; (136 pag.)WO2016/123627; (2016); A1;,
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