Application of 103-64-0,Some common heterocyclic compound, 103-64-0, name is (2-Bromovinyl)benzene, molecular formula is C8H7Br, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
S1: To the appropriate amount of organic solvent DMF, 100 mmol of the compound of the above formula (I), 150 mmol of the compound of the above formula (III), 150 mmol of the amine source cerium ammonium nitrate, 2 mmol of the catalyst dinitrodiammine platinum, 5 mmol of the ligand (3-cyanopropyl) imidazole chloride and 200 mmol sodium hexametaphosphate were added and the temperature was raised to 60 C and the reaction was stirred at that temperature for 8 hours. S1DMF100mmol(I)150mmol(III)150mmol2mmol5mmolL120mmol1,3-(3-)200mmol60C8 Submit CorrectionsCloseS2: After the reaction of step S2 was completed, an aqueous solution of acetic acid having a mass percentage of 20% was added dropwise to the resulting system until the total molar amount of acetic acid added was 200 mmol, and the reaction was stirred at 60 C for 80 minutes. S2S220200mmol60C80 Submit CorrectionsCloseAfter completion of the reaction at step S2, the mixture was poured into ethyl acetate, washed successively with saturated aqueous NaHCO3 and brine, and the aqueous layer was extracted with ethyl acetate. The washed organic layers and the extracted organic layers were combined with anhydrous Na2 SO 4, and the solvent was distilled off under reduced pressure. The residue was purified by flash column chromatography (using n-hexane-ethyl acetate mixture as eluent, volume ratio of 1: 1) to give the compound of the above formula (III) The yield was 95.1%.
The synthetic route of 103-64-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Shanghai Bokang Fine Chemical Co., Ltd.; Fu Zhiwei; (11 pag.)CN104876871; (2017); B;,
Bromide – Wikipedia,
bromide – Wiktionary