Synthetic Route of 58534-95-5,Some common heterocyclic compound, 58534-95-5, name is 3-Bromo-2-fluoroaniline, molecular formula is C6H5BrFN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step 4ATo a solution of 3-bromo-2-fluoroaniline 4a (228 mg) in DCM (5 ml) were added 2,6-difluorobenzene-1-sulfonyl chloride (280 mg), pyridine (120 mg) and DMAP (3 mg). The reaction mixture was stirred overnight at room temperature. iN HC1 was added toquench the reaction, and then the organic phase was washed with brine, dried over Na2504, filtered and concentrated. The residue was purified by chromatography to give desired product 4b (200 mg 47% yield).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Bromo-2-fluoroaniline, its application will become more common.
Reference:
Patent; ETERNITY BIOSCIENCE INC.; LIU, Dong; ZHANG, Minsheng; WO2014/182873; (2014); A1;,
Bromide – Wikipedia,
bromide – Wiktionary