Application of 454-65-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 454-65-9 as follows.
General procedure: A round bottom flask was charged with 4-bromobenzenesulfonyl fluoride 1a (1 equiv), B2(pin)2 (1.1 equiv), Pd(dppf)Cl2CH2Cl2 (3 mol %) and KOAc (3 equiv), evacuated and back-filled with N2 three times. Degassed anhydrous 1,4-dioxane (0.33 M) was added and the reaction was stirred at 80 C for 16 h, then cooled to ambient temperature and concentrated in vacuo. The mixture was diluted with EtOAc, washed sequentially with water and brine, dried with anhydrous MgSO4, filtered and concentrated in vacuo. The crude product was purified by flash column chromatography rapidly to afford the corresponding benzenesulfonyl fluoride boronic acid pinacol ester.
According to the analysis of related databases, 454-65-9, the application of this compound in the production field has become more and more popular.
Reference:
Article; Lou, Terry Shing-Bong; Willis, Michael C.; Tetrahedron; vol. 76; 1; (2020);,
Bromide – Wikipedia,
bromide – Wiktionary