Synthetic Route of 2550-36-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2550-36-9, name is (Bromomethyl)cyclohexane belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
To a solution of 3-(tetrahydro-2H-pyran-4-yl)imidazo[1 ,5-a]pyrazin-8(7H)-one (300 mg, 1 .37 mmol) in anhydrous DMF (5 mL) was added K2003 (379 mg, 2.74mmol) and (bromomethyl)cyclohexane (364 mg, 2.06 mmol). The reaction mixture was stirred at 60C for 16 hours. The mixture was filtered and the filtrate was purified by preparative LC-MS to yield 7-(cyclohexylmethyl)-3-(tetrahydro-2H-pyran-4-yl )imidazo[1 ,5-a]pyrazin-8(7H)-one 240 mg (55%).1H NMR (DMSO-d6, 400 Mhz): 7.62 (s, 1H), 7.47 (d, J= 6.0 Hz, 1H), 6.84 (d, J= 6.2 Hz,1H), 3.91-3.88 (m, 2H), 3.60 (d, J= 7.2 Hz, 2H), 3.48-3.42 (m, 2H), 3.30-3.29 (m, 1H), 1.78-1.52 (m, 1OH), 1.10-1.06 (m, 3H), 0.93-0.91 (m, 2H).LC-MS: (mlz) 316.2 (MH) tR (minutes, method 3) = 2.44 minutes.
The synthetic route of (Bromomethyl)cyclohexane has been constantly updated, and we look forward to future research findings.
Reference:
Patent; H. LUNDBECK A/S; KEHLER, Jan; RASMUSSEN, Lars, Kyhn; LANGGARD, Morten; JESSING, Mikkel; VITAL, Paulo, Jorge, Vieira; JUHL, Karsten; (159 pag.)WO2016/174188; (2016); A1;,
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