Electric Literature of 3814-30-0, The chemical industry reduces the impact on the environment during synthesis 3814-30-0, name is (Bromomethyl)cyclopentane, I believe this compound will play a more active role in future production and life.
Example 4 7-(Cyclopentylmethyl)-3-propyl-[1,2,4]triazolo[4,3-a]pyrazin-8(7H)-one: To a solution of 3-propyl-[1 ,2,4]thazolo[4,3-a]pyrazin-8(7H)-one (200 mg, 1 .1 mmol) and (bromomethyl)cyclopentane (283 mg, 1 .35 mmol) in DMF (2 ml_) was added K2CO3 (310 mg, 2.2 mmol). The reaction was stirred at 60 C for 4 hours and then cooled to RT. The mixture was diluted with DCM (20 ml_) and washed with water (2×5 ml_). The organic layer was dried over Na2SO4 and evaporated. The crude product was washed with MeOH (2 ml_) to give 7-(cyclopentylmethyl)-3-propyl- [1 ,2,4]triazolo[4,3-a]pyrazin-8(7H)-one 120 mg (41 %) . 1H NMR (CDCI3, 400 MHz TMS): delta 6.91 (d, J=5.6 Hz, 1 H), 6.66 (d, J=5.6 Hz, 1 H), 3.89 (d, J=8.0 Hz, 2H), 2.94 (t, J=7.6 Hz, 2H), 2.37-2.31 (m, 1 H), 1 .92-1 .86 (m, 2H), 1 .73-1 .68 (m, 4H), 1 .63-1 .56 (m, 2H), 1 .32-1 .27 (m, 2H), 1 .04 (t, J=7.4 Hz, 3H). LCMS (MH+): m/z = 261 .1 , tR (minutes, Method 3) = 2.41
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (Bromomethyl)cyclopentane, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; H. LUNDBECK A/S; KEHLER, Jan; RASMUSSEN, Lars, Kyhn; JESSING, Mikkel; (126 pag.)WO2016/55618; (2016); A1;,
Bromide – Wikipedia,
bromide – Wiktionary