Related Products of 1435-52-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1435-52-5 name is 1,4-Dibromo-2-fluorobenzene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
General procedure: 6.13 1-(4′-Ethylphenyl)-4-(4″-ethylphenyl)-2-fluorobenzene (7m): Starting with 6 (200 mg, 0.79 mmol), Cs2CO3 (385 mg, 1.81 mmol), Pd(PPh3)4 (3 molpercent), 4-ethylphenylboronic acid (237 mg, 1.58 mmol) and 1,4-dioxane (4 mL), 7m was isolated as a colorless solid (195 mg, 81percent). Mp 111 °C. 1H NMR (300 MHz, CDCl3): delta = 1.20 (t, J = 15.2 Hz, 7.5 Hz, 3H, CH3), 1.22 (t, J = 15.2 Hz, 7.5 Hz, 3H, CH3), 2.62 (t, J = 15.1 Hz, 7.4 Hz, 4H, 2CH2), 7.19-7.22 (m, 4H, ArH), 7.27-7.40 (m, 3H, ArH), 7.42-7.47 (m, 4H, ArH). 13C NMR (75 MHz, CDCl3): delta = 15.6 (d, J = 2.2 Hz, 2CH3), 28.6 (d, J = 5.5 Hz, 2CH2), 114.4 (CH), 114.5 (CH), 122.7 (d, J = 4.0 Hz, CH), 126.9 (2CH), 127.4 (d, J = 13.8 Hz, C), 128. (2CH), 128.5 (2CH), 128.9 (d, J = 4.0 Hz, CH), 130.8 (d, J = 4.0 Hz, CH), 132.9 (C), 136.9 (C), 141.9 (d, J = 8.3 Hz, C), 143.9 (d, J = 20.9 Hz, CH), 160.1 (d, JCF = 247.0 Hz, CF). 19F NMR (282 MHz, CDCl3): delta = -117.24 (CF). IR (ATR, cm-1): , 2963 (w), 2873 (w), 2361 (w), 1609 (w), 1544 (w), 1485 (w), 1428 (w), 1394 (w), 1295 (w), 1260 (w), 1180 (w), 1135 (w), 1050 (w), 1004 (w), 970 (w), 889 (w), 814 (w), 728 (w), 696 (w), 641 (w), 582 (w), 499 (w), 417 (w) cm-1. GC-MS (EI, 70 eV): m/z (percent) = 304 (100) [M]+, 290 (18), 289 (80), 274 (21), 137 (17). HRMS (ESI) calcd. for C22H22F [M + H]+: 305.17001; found 305.16948. Anal. calcd. for C21H17FO2: C,86.85. H, 6.91. Found: C, 86.82. H, 6.88.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1,4-Dibromo-2-fluorobenzene, and friends who are interested can also refer to it.
Reference:
Article; Sharif, Muhammad; Maalik, Aneela; Reimann, Sebastian; Feist, Holger; Iqbal, Jamshed; Patonay, Tama?s; Villinger, Alexander; Langer, Peter; Journal of Fluorine Chemistry; vol. 146; (2013); p. 19 – 36;,
Bromide – Wikipedia,
bromide – Wiktionary