In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 57951-72-1, name is 1-Bromo-2-cyclopropylethyne belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. HPLC of Formula: C5H5Br
To a solution of (bromoethynyl)cyclopropane (60 g, 414 mmol) in piperidine (345 ml) at 0 C. was added ethynyltrimethylsilane (44.7 g, 455 mmol) and CuI (7.88 g, 41.4 mmol). The solution was then stirred at rt for 2 hours. The reaction was quenched by adding sat. aq. NH4Cl solution and then extracted with TBME. The organic layer was washed with water, brine, dried over MgSO4 and concentrated. The crude material was purified by silica gel column chromatography, heptane as eluant to give product (42 g, 62% yield). 1H NMR (400 MHz, CDCl3) 0.13-0.24 (m, 9H) 0.72-0.91 (m, 4H) 1.25-1.36 (m, 1H)
The synthetic route of 57951-72-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Novartis AG; FU, Jiping; JIANG, Siyi; KORDIKOWSKI, Andreas; SWEENEY, Zachary Kevin; (21 pag.)US2017/355684; (2017); A1;,
Bromide – Wikipedia,
bromide – Wiktionary