Application of 630-17-1, A common heterocyclic compound, 630-17-1, name is 1-Bromo-2,2-dimethylpropane, molecular formula is C5H11Br, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: (3 mL) was added the electron-deficient alkene (6 mmol) at room temperature. Under vigorous stirring, NiCl2*6H2O (475 mg,2 mmol) was added to the above mixture. The temperature thenrose to 50 C, and stirring was continued for 20 min. The resulting red-brown Ni(0) complex was cooled to room temperature, and a solution of the alkyl bromide (2 mmol) in pyridine (1 mL) was added dropwise. The mixture was stirred for 0.5 h, and then filtered with a short plug (elution with 50 mL of Et2O) and washed with HCl(1N), water and brine, dried over MgSO4, filtered and concentrated. The crude product was purified by flash chromatography on silicagel to afford desired ester products.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Ouyang, Yan; Peng, Yu; Li, Wei-Dong Z.; Tetrahedron; vol. 75; 33; (2019); p. 4486 – 4496;,
Bromide – Wikipedia,
bromide – Wiktionary