Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6274-57-3, name is 1-(4-Bromophenyl)-N,N-dimethylmethanamine, A new synthetic method of this compound is introduced below., Recommanded Product: 1-(4-Bromophenyl)-N,N-dimethylmethanamine
To a 1 L round bottom flask with a stir bar, reflux condenser and gas inlet containing [4-bromophenyl)methyl]dimethyl amine (55 mmol, 11.8 g) in glyme (300 mL) and water (30 mL) was added 3-aminophenyl boronic acid hydrate (110 mmol, 17g), (Ph3P)2PdCI2 (2.75 mmol, 1.93 g) and sodium carbonate (165 mmol, 17.5 g). The reaction was stirred at reflux under nitrogen until LC-MS analysis indicated consumption of starting material. The reaction mixture was partitioned between diethyl ether and water. The organic layer was washed with brine, dried (Na2SO4), filtered, and concentrated to give an oil. The oil was slurried in Et2O and acidified with 1N HCI in Et2O to give the HCI salt of the product as a precipitate (12 g, 73%). 1H NMR (300 MHz, DMSO-d6) delta ppm 8.15 (br s, 2H), 7.58 (d, 1 H, J = 7.3), 7.52 (d, 1H, J = 1.8), 7.34 (t, 1 H, J = 7.7), 7.22 (m, 2H)1 7.06 (m, 2H), 6.79 (d, 1H, J = 7.8), 4.32 (s, 2H), 2.73 (s, 6H)
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2007/18941; (2007); A2;,
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bromide – Wiktionary