Electric Literature of 630-17-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 630-17-1, name is 1-Bromo-2,2-dimethylpropane belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
N- (benzyloxycarbonyl) acetamide potassium salt(231 mg, 1.00 mmol) and 18-crown-6 (264 mg, 1.00 mmol)Was dissolved in dimethylformamide (1 mL).After adding 1-bromo-2-chloroethane (83 mL, 1.00 mmol)And the mixture was stirred at room temperature for 19.5 hours.The reaction was terminated by adding saturated aqueous ammonium chloride solution (about 3 mL)The reaction mixture was extracted with ethyl acetate.After washing the organic layer with water and saturated brine,And dried over anhydrous magnesium sulfate.Flash silica gel chromatography(20% ? 40% ethyl acetate / n-hexane)N- (benzyloxycarbonyl) -N- (2-chloroethyl) acetamide(137 mg, 54%) of a colorless oil.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-2,2-dimethylpropane, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; School corporation Meijo University; Mori, Yuji; Sakai, Takeo; Fukuda, Ayumi; Kasai, Satomi; (28 pag.)JP2018/95576; (2018); A;,
Bromide – Wikipedia,
bromide – Wiktionary