Related Products of 626-88-0, A common heterocyclic compound, 626-88-0, name is 1-Bromo-4-methylpentane, molecular formula is C6H13Br, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Into a 15-mL sealed tube, was placed a solution of 1-bromo-4-methylpentane (5 g, 30.30 mmol, 2.00 equiv) in 1,3-dimethylimidazolidin-2-one (20 mL), methyl 4-iodobenzoate (4 g, 15.27 mmol, 1.00 equiv), NiI2.6H2O (0.68 g, 1.62 mmol, 0.11 equiv), Mn (1.66 g, 30.18 mmol, 2.00 equiv), pyridine (0.12 g, 1.52 mmol, 0.10 equiv), 4,4′-di-tert-butyl-2,2′-bipyridine (0.204 g, 0.76 mmol, 0.05 equiv) and 1,2-bis(diphenylphosphino)benzene (0.338 g, 0.76 mmol, 0.05 equiv). The reaction mixture was stirred overnight at 85 C. in an oil bath and then quenched by the addition of 100 mL of water, then cooled to room temperature. The resulting mixture was extracted with 3*100 mL of ethyl acetate. The combined organic layers were dried over anhydrous sodium sulfate and concentrated under vacuum. The residue was applied onto a silica gel column and eluted with petroleum ether (100%) to yield of methyl 4-(4-methylpentyl)benzoate as colorless oil.
The synthetic route of 626-88-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Janssen Pharmaceutica NV; Gaul, Micheal; Xu, Guozhang; Zhao, Bao-Ping; (53 pag.)US2018/64686; (2018); A1;,
Bromide – Wikipedia,
bromide – Wiktionary