Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 3344-70-5, name is 1,12-Dibromododecane, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C12H24Br2
Example 11 (n=12); (a) 1,1′-[(Dodecane-1,12-diyl)dioxy]bis[(11S,11aS)-10-(tert- butyloxycarbonyl)-8-methoxy-11- (tetrahydro-pyran-2-yloxy)- 1, 2, 3, 10, 11, 11a-hexahydro-5H-pyrrolo[2,1-c][1,4]benzodiazpeine-5- one] (8j); 1,12-Dibromododecane (73.1 mg, 0.22 mmol, 0.5 equiv) was added to the mixture of monomer 7 (0. 2 g, 0.44 mmol, 1.0 equiv) potassium carbonate (0.98 mmol, 2. 2 equiv) and a catalytic amount of potassium iodide in dry DMF (30 mL), and the resulting mixture was heated to 90°C under a nitrogen atmosphere for 5 h. Removal of excess solvent under reduced pressure afforded a crude solid, which was subjected to flash column chromatography (SiO2, 50percent EtOAc- hexane) to afford the dimerized compound 8j (208 mg, 0.19 mmol, 87percent yield, mixture of diastereomers from THP protecting group) as a solid: [alpha]20D = +50° (c = 0.20, CHC13) ; 1H NMR (CDCl3, 400 MHz): No. 1.26-1. 68 (m, 84H, 14-H, 15-H, 16-H, 17-H, Boc, THP), 1.69-1. 89 (16H, 13-H, THP), 1.93-2. 20 (m, 16H, 1-H, 2-H), 3.44-3. 75 (m, 16H, 3-H, lla-H, THP), 3.83-4. 14 (m, 24H, 12-H, 7-OMe, THP), 5.02-5. 10 (m, 2H, THP), 5.12-5. 19 (m, 2H, THP), 5.69-5. 77 (d, 2H, 11-H), 5.79-5. 89 (d, 2H, 11-H), 6.50 (s, 2H, 9-H), 6.87 (s, 2H, 9-H), 7.19 (s, 2H, 6-H), 7.22 (s, 2H, 6-H) ;”C NMR (CDCl3, 400 MHz): 5 19.9, 20.4, 23.1, 23.2, 25.2, 25.3, 25.9, 28.1, 28.2, 28.9, 29.0, 29.1, 29.2, 29.3, 29.56, 29.58, 30.9, 31.2, 46.2, 55.9, 56.2, 60.0, 60.1, 63.3, 64.4, 69.12, 69.15, 80. 9,81. 2,88. 2,91. 2, 95.8, 100.2, 111.1, 111.5, 113.4, 114.0, 126.3, 129.6, 134. 1, 138.8, 147.8, 148.1, 151.5, 155.3, 167.4, 167.6 ; IR (neat): 2932, 1703,1643, 1604,1513, 1450,1392, 1327,1218, 1164, 1022cm~1 ; MS (FAB) m/z (relative intensity) 1085 ( + Na] +, 28), 1063 (M 100), 961 (17), 861 (13).
According to the analysis of related databases, 3344-70-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; SPIROGEN LIMITED; WO2005/85259; (2005); A2;,
Bromide – Wikipedia,
bromide – Wiktionary