Adding a certain compound to certain chemical reactions, such as: 68322-84-9, name is 2-Bromo-1-fluoro-4-(trifluoromethyl)benzene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 68322-84-9, Quality Control of 2-Bromo-1-fluoro-4-(trifluoromethyl)benzene
EXAMPLE 60 (2S)-1-[((2S,5R)-5-{[2-bromo-4-(trifluoromethyl)phenoxy]methyl}pyrrolidin-2-yl)carbonyl]pyrrolidine-2-carbonitrile The compound of Example 14A (50 mg, 0.15 mmol) and 3-bromo-4-fluorobenzotrifluoride (30 muL, 0.2 mmol) were stirred in DMF (1 mL) under N2. NaH (13 mg, 0.3 mmol) was added to the mixture. It was stirred at room temperature for I hour. After the reaction was over, the mixture was purified by reverse-phase HPLC to give the Boc-protected compound (40% yield). MS (ESI) m/z 546, 548 (M+H)+. The Boc group was removed according to Example 1G to give the title compound. 1H NMR (500 MHz, MeOH-d4) delta ppm 2.05-2.44 (m, 7 H), 2.49-2.65 (m, 1 H), 3.50-3.59 (m, 1 H), 3.62-3.74 (m, 1 H), 4.20-4.32 (m, 1 H), 4.47-4.58 (m, 2 H), 4.68-4.76 (m, 1 H), 4.81-4.90 (m, 1 H), 7.27 (dd, J=8.42, 4.05 Hz, 1 H), 7.69 (d, J=8.73 Hz, 1 H), 7.85-7.94 (m, 1 H). MS (ESI) m/z 446, 448 (M+H)+.
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Reference:
Patent; Pei, Zhonghua; Li, Xiaofeng; Longenecker, Kenton L.; Sham, Hing L.; Wiedeman, Paul E.; US2005/131019; (2005); A1;,
Bromide – Wikipedia,
bromide – Wiktionary