The origin of a common compound about 59734-92-8

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 59734-92-8, name is 1-Bromo-2-cyclohexylbenzene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. SDS of cas: 59734-92-8

Example 82; Synthesis of 2-(2-cyclohexylphenylami?o)-3H-benzimidazole-5-carboxylic acid (lH-indazol-6-yl)-amideTo a solution of l-bromo-2-cyclohexyl-benzene (5 mmol) in dioxane (20 mL) was added solid Pd(OAc)2 (0.1 g) and solid CsCO3 (10 mmol). tert-Buty] carbamate (7 mmol) was added to the reaction mixture, and the contents were heated at 80 0C for 2 h. The reaction mixture was cooled to room temperature and filtered through Celite. The solvent was removed in vacuo and the residue obtained was purified by flash column chromatography using DCM as elupsilonant to yield (2-cyclohexylphenyI)-carbamic acid tert-hvtiy ester.The carbamate obtained as above was treated with 4 M HCl in dioxane following the procedure described in Example 80 to afford 2-cyclohexylphenylamine as a hydrochloride salt.To a solution of aforementioned amine hydrochloride (1 mmol) in dry DMF (2 mL) was added DIEA (1.5 mmol) and lj’-thiocarbonylimidazole (1 mmol). The reaction mixture was heated at 700C for Ih to provide l-cyclohexyl-2-isothiocyanatobenzene as described in general procedure A.The isothiocyanate (0.5 mmol) was reacted with 3,4-diamino-N-(lH-mdazol-6-yl)- benzamide (0.5 mmol; see Example 25) according to general procedure B to yield 2-(2- cyclohexylphenylamino)-3H-benzimidazole-5-carboxylic acid (lH-indazol-6-yl)-amide. MS: m/z 451 (M+H)+.

The synthetic route of 59734-92-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; TRANSTECH PHARMA, INC.; WO2007/95124; (2007); A2;,
Bromide – Wikipedia,
bromide – Wiktionary