Electric Literature of 28342-75-8,Some common heterocyclic compound, 28342-75-8, name is 1,5-Dibromo-2,4-difluorobenzene, molecular formula is C6H2Br2F2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
1,5-dibromo-2,4-difluorobenzene(30 g, 110.3 mmol)And cyanocopper(22.7 g, 253.7 mmol)After dissolving in DMF (120 ml), it was made into nitrogen atmosphere, and the temperature was raised, and the mixture was refluxed with stirring for 17 hours.The reaction solution was extracted with MC and then subjected to column chromatography using an ethyl acetate / hexane mixed solvent as eluent to obtain 6.0 g of Intermediate 1.
The synthetic route of 28342-75-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Cheil Industries Co., Ltd.; Dankook University Academic Cooperation; Lee, Sang Sin; Yu, Uhn Sun; Lee, Jun Yeop; Jo, Yong Ju; Choe, Yun Ho; (26 pag.)KR2016/331; (2016); A;,
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