Synthetic Route of 69272-50-0, The chemical industry reduces the impact on the environment during synthesis 69272-50-0, name is 3,6-Dibromobenzene-1,2-diamine, I believe this compound will play a more active role in future production and life.
In a dry 100 mL flask, compound 1 (0.59 g, 2 mmol) and NaBH4 (0.76 g, 20 mmol) were mixed inethanol (40 mL) for 1 h at RT, and then refluxed for 4 h under a nitrogen atmosphere. After coolingto RT, water was added and filtered. The residue was dried in vacuum. Then the crude product andsodium acetate (0.33 g, 4 mmol) were added to a solution of benzil (0.42 g, 2 mmol) in anhydrousethanol (30 mL) under a nitrogen atmosphere. The mixture was refluxed for 24 h. After cooling to RT,the solvent was removed under reduced pressure and the residue was purified by silica gel columnchromatography (eluent: n-hexane:CH2Cl2 = 4:1) to give a pale yellow solid (yield 72.0%, 0.75 g).1H-NMR (400 MHz, CDCl3,delta ): 7.91(s, 2H), 7.65-7.66(m, 4H), 7.34-7.41(m, 6H). 13C-NMR (100 MHz,CDCl3,delta ): 154.15, 139.36, 137.95, 133.10, 130.26, 129.59, 128.38, 123.74.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,6-Dibromobenzene-1,2-diamine, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Wu, Zhonglian; Jiang, Huanxiang; Wang, Xingzhu; Yan, Lei; Zeng, Wei; Wu, Xiu-Gang; Zhuang, Haiyu; Zhu, Wen; Yang, Renqiang; Molecules; vol. 24; 1; (2019);,
Bromide – Wikipedia,
bromide – Wiktionary