In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 103-64-0, name is (2-Bromovinyl)benzene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Safety of (2-Bromovinyl)benzene
General procedure: To a solution of CoBr2 (22 mg, 0.10 mmol, 10 mol%), bis-1,2-diphenylphosphinopropane (41.2 mg, 0.10 mmol, 10 mol%), and manganese powder (165 mg, 3 mmol, 3 equiv) in acetonitrile (5 mL) was added the aryl bromide (2 mmol, 2 equiv) at the desired temperature (rt for the bromo eneformamides or 40C for the bromo enecarbamates). A solution of the bromo eneformamide (1 mmol, 1 equiv) in acetonitrile (5 mL) was added slowly. After completion (as judged by TLC and GC-MS), the reaction mixture was treated with a mild acid such as 10% H3PO4 (aq) and extracted with CH2Cl2. The combined organic layers were dried over MgSO4, filtered and concentrated under reduced pressure to afford the desired coupling product as an oil. Purification was carried out by flash chromatography on silica (pretreated with 1% Et3N).
The synthetic route of 103-64-0 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Bassler, Daniel P.; Alwali, Amir; Spence, Laura; Beale, Oliver; Beng, Timothy K.; Journal of Organometallic Chemistry; vol. 780; (2015); p. 6 – 12;,
Bromide – Wikipedia,
bromide – Wiktionary