Some common heterocyclic compound, 17247-58-4, name is (Bromomethyl)cyclobutane, molecular formula is C5H9Br, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of (Bromomethyl)cyclobutane
A stirred solution of ketimine 10.01 (50 g, 187.1 mmol) under N2 in dry THF (400 mL) was cooled to-78 C and treated with 1 M solution of K-tBuO (220 mL, 1.15 equiv. ) in THF. The reaction mixture was warmed to 0 C and stirred for 1 h and treated with bromomethyl cyclobutane (28 mL, 249 mmol). The reaction mixture was stirred at room temperature for 48 h and concentrated in vacuo. The residue was dissolved in Et20 (300 mL) and treated with aq. HCI (2 M, 300 mL) The resulting solution was stirred at room temperature for 5 h and extracted with Et20 (1 L). The aqueous layer was made basic to pH-12-14 with NaOH (50 % aq. ) and extracted with CH2CI2 (3×300 mL). The combined organic layers were dried (MgS04), filtered, and concentrated to give the pure amine (10.02, 18 g) as a colorless oil.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 17247-58-4, its application will become more common.
Reference:
Patent; SCHERING CORPORATION; WO2005/85197; (2005); A1;,
Bromide – Wikipedia,
bromide – Wiktionary