Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 67344-77-8, name is 1-(3-Bromophenyl)-N-methylmethanamine, A new synthetic method of this compound is introduced below., Recommanded Product: 1-(3-Bromophenyl)-N-methylmethanamine
0. 15 g of tetrakistriphenylphosphine palladium was added at room temperature to a solution having 0.8 g of N-methyl-3-bromobenzylamine dissolved in 10 ml of toluene, followed by stirring for 5 minutes. 0.76 g of 2,4, 6- trimethylphenyl boronic acid, 3 ml of ethanol and 4.5 ml of a 2M sodium carbonate aqueous solution were sequentially added to this solution, followed by stirring for 4 hours under reflux. After cooling, 50 ml of ethyl acetate and 50 ml of a 5percent ammonium chloride aqueous solution were added, followed by stirring for a while. Then, liquid separation was carried out. The water layer was further extracted with 30 ml of ethyl acetate. Then, the organic layers were put together and dried over anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure. The obtained crude product was purified by silica gel (Silica gel 60N; spherical and neutral, manufactured by Kanto Kagaku) column chromatography (developing solvent of n-hexane: ethyl acetate=1 : 1) to obtain 0.55 g of the objective compound as an oily substance. Further, NMR of this compound was as follows. 1H-NMR 5 (ppm) 2.00 (s, 6H), 2.08 (bs, lH), 2.33 (s, 3H), 2.46 (s, 3H), 3.80 (s, 3H), 6.93 (s, 2H), 7.41 (d, lH; J =7. 5 Hz), 7.08 (s, lH), 7.29 (d, lH; J =7. 5 Hz), 7.38 (t, lH; J =7.5 Hz)
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; ISHIHARA SANGYO KAISHA, LTD.?; WO2005/44007; (2005); A1;,
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bromide – Wiktionary