In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 17247-58-4, name is (Bromomethyl)cyclobutane belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Quality Control of (Bromomethyl)cyclobutane
A mixture of 4-(tetramethyl-1 ,3, 2-dioxaborolan-2-yl)-1H-pyrazole (0.58 g, 2.96 mmol), (bromomethyl)cyclobutane (0.50 ml_, 4.44 mmol) and potassium carbonate (1 .23 g, 8.88 mmol) in N,N-dimethylformamide (6 mL) was heated at 100 C for 20 hours. The reaction mixture was cooled to RT, diluted with EtOAc (50 mL) and water (50 mL). The organic layer was separated, washed with water (50 mL) and brine (30 mL), dried (MgS04), concentrated under reduced pressure and purified by Biotage Isolera chromatography (25 g Silica column, using a gradient of eluents; 0-30% EtOAc in heptane) to afford the title compound (330 mg, 41 % yield) as a colourless oil. 1H NMR (250 MHz, chloroform-d) delta [ppm] 7.76 (s, 1 H), 7.64 (s, 1 H), 4.13 (d, J = 7.3 Hz, 2H), 2.95 -2.70 (m, 1 H), 2.20 – 1 .64 (m, 6H), 1 .31 (s, 12H). LCMS (Analytical Method A): Rt = 1 .13 min, MS (ESIpos): m/z = 262.9 (M+H)
The synthetic route of 17247-58-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; BAeURLE, Stefan; DAVENPORT, Adam, James; STIMSON, Christopher; NAGEL, Jens; SCHMIDT, Nicole; ROTGERI, Andrea; GROeTICKE, Ina; RAUSCH, Alexandra; KLAR, Juergen; DYRKS, Thomas; (422 pag.)WO2018/114786; (2018); A1;,
Bromide – Wikipedia,
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