Electric Literature of 22385-77-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 22385-77-9 as follows.
In a 500mL dry three-necked bottle, Compound 9 (23.8 g, 0.1 mol) was first dissolved in 200 mL of dry tetrahydrofuran. The flask was placed at -10 ° C. Compound 10 was slowly added (26.9 g, 0.1 mol) And t-BuLi (60 mL, 1 M in THF, 60 mmol), The reaction was carried out for 20 h under a nitrogen atmosphere. After the reaction, water is added to quench the reaction. Then with ethyl acetate, Water extraction reaction, Dry over anhydrous sodium sulfate, Concentrated under reduced pressure, Further column chromatography gave Compound 8 (21 g, 50percent).
According to the analysis of related databases, 22385-77-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Wanhua Chemical Group Co., Ltd.; Wang Zesheng; Cong Xin; He Guangwen; Liu Chao; Dong Ke; Wang Peng; Cui Qian; Yu Yanbing; (12 pag.)CN109134538; (2019); A;,
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