Synthetic Route of 112734-22-2, These common heterocyclic compound, 112734-22-2, name is (4-Bromo-2-fluorophenyl)methanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Step 1 : To a stirred solution of (4-bromo-2-fluorophenyl)methanamine (2.5 g, 12.25 mmol) in pyridine (10 mL) at 0 C in a protective gas atmosphere was added methanesulfonyl chloride (1 .422 mL, 18.38 mmol) slowly in portions. After addition, the suspension was stirred at 0 C for 1 h. The reaction mixture was diluted with ice cold water (20 mL) and pH was adjusted to ~1 using 16 % aqueous HCI solution. The resulting precipitation was filtered off, washed with ethyl acetate (3 x 20 mL) and dried overnight. The crude N-(4-bromo-2-fluorobenzyl)- methanesulfonamide (3.14 g, 91 %) was used as such without further purification.
The synthetic route of 112734-22-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GRUeNENTHAL GMBH; FRANK, Robert; BAHRENBERG, Gregor; CHRISTOPH, Thomas; LESCH, Bernhard; LEE, Jeewoo; WO2013/45451; (2013); A1;,
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bromide – Wiktionary