Reference of 61613-22-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 61613-22-7, name is 2-Bromo-N-phenylaniline, This compound has unique chemical properties. The synthetic route is as follows.
In a 200 mL three-neck flask equipped with a reflux tube, BrDPA (4.96 g, 20 mmol), di-tert-butyl dicarbonate (7.7 ml, 35 mmol), N, N-dimethyl-4-aminopyridine (0.37 g) , 3 mmol) and 150 ml of dehydrated tetrahydrofuran. The mixture was heated to reflux for about 20 hours. When the progress of the reaction was confirmed by TLC, consumption of the raw materials and spots that seemed to be the target substance were confirmed. The reaction was terminated, and the temperature was returned to room temperature. After returning to room temperature, concentration was performed. Thereafter, purification was performed by column chromatography (developing solvent ratio: n-hexane: dichloromethane = 1: 1) to obtain 5.89 g (yield = 85%) of the desired product. Identification was performed by 1H-NMR.
The chemical industry reduces the impact on the environment during synthesis 2-Bromo-N-phenylaniline. I believe this compound will play a more active role in future production and life.
Reference:
Patent; Flask Co., Ltd.; Sasabe, Hisahiro; Kido, Junji; Arai, Hiroki; Nakao, Kohei; (21 pag.)JP2020/26399; (2020); A;,
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bromide – Wiktionary